Methylguard 180 Caps Thorne Research
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Strengthen your metabolic pathways with efficient methylation support and high-quality B vitamins.
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Description
5-MTHF Folate with Vitamin B12, B6, and Betaine to support methylation and homocysteine balance — Thorne
Methylation is an essential biochemical process that occurs continuously in the body — involving DNA function, neurotransmitter production, liver detoxification, homocysteine metabolism, and much more. Thorne's 5-MTHF Folate with Vitamin B12, B6, and Betaine (Methyl-Guard) was the first supplement on the market to support methylation with nutrients in their active and bioavailable forms — 5-MTHF folate (Quatrefolic®), methylcobalamin, pyridoxal 5'-phosphate, and betaine (trimethylglycine). This combination can support normal homocysteine metabolism, contributing to cardiovascular, cognitive, and bone well-being. Formulated without gluten, lactose, and soy, with a vegetable capsule and produced in the USA according to Thorne's quality standards.
Thorne's Methyl-Guard is a supplement of B vitamins in their active forms combined with betaine, designed for those who want to support methylation and normal homocysteine metabolism — especially adults with genetic variants that affect folate conversion (such as the MTHFR variant), or those who want to support cardiovascular, cognitive, and bone health with bioavailable nutrients.
Thorne's Methyl-Guard combines four nutrients with distinct and complementary roles in supporting methylation:
5-MTHF Folate (L-5-Methyltetrahydrofolate, Quatrefolic®, 1.2 mg = 2 mg DFE per dose) is the biologically active form of folate, which the body can use directly without the need for metabolic conversion by the MTHFR enzyme. This is particularly relevant for people with genetic variants that reduce the activity of this enzyme (C677T or A1298C variant of the MTHFR gene), making conventional folic acid supplementation less effective. Folate is an essential cofactor in the remethylation pathways of homocysteine to methionine.
Vitamin B12 (as Methylcobalamin, 1.2 mg per dose) is the active form of vitamin B12, which the body can use directly as an enzymatic cofactor. Methylcobalamin acts as a methyl group donor in methylation pathways, being essential for normal homocysteine metabolism, nervous system function, and normal red blood cell formation.
Vitamin B6 (as Pyridoxal 5'-Phosphate, 20.4 mg per dose) is the active coenzymatic form of vitamin B6, an essential cofactor in the transsulfuration pathways of homocysteine — the alternative pathway that converts homocysteine into cysteine and taurine, amino acids beneficial to the body. This active form does not require hepatic conversion, and may be more effective in contexts of methylation support.
Anhydrous Betaine (Trimethylglycine, TMG, 1.8 g per dose) is a natural compound present in foods such as beetroot. It functions as a methyl group donor independently of B vitamins, serving as an alternative pathway for remethylation of homocysteine to methionine — especially relevant when folate-dependent pathways are compromised.
Important considerations
- Interaction with methotrexate: 5-MTHF supplementation is not recommended concurrently with methotrexate in oncological chemotherapy, as it may interfere with its antineoplastic action. Those taking methotrexate for psoriasis or rheumatoid arthritis can safely take folate — always consult a doctor.
- Intended for adults; consult a healthcare professional if pregnant, breastfeeding, or taking regular medication before starting.
- People sensitive to methylation (hypermethylators) may experience symptoms such as anxiety or irritability with high doses — start with lower doses and adjust gradually.
✅ May contribute to normal homocysteine metabolism (folate, B6, and B12)
✅ May support psychological function and the nervous system (B12, folate)
✅ May help reduce tiredness and fatigue
✅ Contains 5-MTHF (Metafolin®), methylcobalamin, and P5P – bioactive forms
✅ Ideal for those with genetic mutations like MTHFR
✅ Pure formula, free from gluten, soy, or artificial additives
Thorne Methyl-Guard® is a balanced formula for cellular methylation support, a fundamental biochemical process for gene expression, detoxification, neurotransmitter synthesis, and cardiovascular system regulation.
How to Use: 3 Capsules daily or as directed by a doctor.
Nutritional Information
Vitamin B12 (as methylcobalamin), 1200 µg / 48000%
Betaine, 1800 mg / **
Vitamin B6 (Pyridoxal 5- Phosphate), 20.4 mg / 1457%
Ingredients:Trimethylglycine, hypromellose capsule (vegetable), calcium citrate laurate (flow agent), silicon dioxide (anti-caking agent), pyridoxal-5-phosphate, 5-MTHF-glucosamine, methylcobalamin
Food Preferences
- Vegano
- Não tem glúten
- Sem soja
- Sem corantes artificiais
- Sem aromas artificiais
- Sem adoçantes artificiais
- Sem lactose
- Sem OGM
- Sem conservantes
Suitable for various diets
- Vegano
- Não tem glúten
- Sem soja
- Sem corantes artificiais
- Sem aromas artificiais
- Sem adoçantes artificiais
- Sem lactose
- Sem OGM
- Sem conservantes
- Vegano
- Não tem glúten
- Sem soja
- Sem corantes artificiais
- Sem aromas artificiais
- Sem adoçantes artificiais
- Sem lactose
- Sem OGM
- Sem conservantes
FAQs
Can people with elevated homocysteine levels benefit from this formula?
Elevated homocysteine is a marker for cardiovascular and cognitive risk. 5-MTHF folate, vitamin B12 (methylcobalamin), vitamin B6 (P5P), and betaine are the four most studied nutrients in supporting normal homocysteine metabolism. Individuals with elevated levels should supplement under medical supervision and with regular analytical monitoring.
Can people with chronic fatigue, "brain fog" or difficulty concentrating benefit from this formula?
Folate can contribute to normal psychological function and the reduction of fatigue. Vitamin B12 can contribute to the normal functioning of the nervous system. Those experiencing mental fatigue or difficulty concentrating may consider this supplement as part of a cognitive wellness approach, especially if they have a B12 deficiency or an MTHFR variant.
Is this formula suitable for women who are pregnant or planning to become pregnant?
Folate is an essential nutrient during pregnancy. However, the doses present in this formula are high and intended for adults in general - it is mandatory to consult a gynaecologist or doctor before using during pregnancy or during family planning.
Notices
* NRV (Nutrient Reference Value)
** VRN not established.
Food supplements are not a substitute for a varied and balanced diet or a healthy lifestyle. If you are pregnant or breastfeeding, please contact your doctor before taking the supplements. Not recommended in cases of hypersensitivity or allergy to any of the ingredients in the formulation or when interactions of another product with any of the constituents of the formulation are described. Keep out of the reach and sight of children. Store in a cool, dry place, protected from light.
The recommended daily dose should not be exceeded.
Notices
* NRV (Nutrient Reference Value)
** VRN not established.
Food supplements are not a substitute for a varied and balanced diet or a healthy lifestyle. If you are pregnant or breastfeeding, please contact your doctor before taking the supplements. Not recommended in cases of hypersensitivity or allergy to any of the ingredients in the formulation or when interactions of another product with any of the constituents of the formulation are described. Keep out of the reach and sight of children. Store in a cool, dry place, protected from light.
The recommended daily dose should not be exceeded.
