Riboflavin 5 - Phosphate 60 Caps Thorne Research

Thorne Riboflavin 5-Phosphate – Active Vitamin B2 for Cellular Energy and Fatigue Reduction

Thorne Riboflavin 5-Phosphate is a vitamin B2 supplement in its active coenzyme form (R5P), ready to be used by the body without additional liver conversion. It can be beneficial for those looking to support energy production, normal metabolism, the activation of other B vitamins, and daily cellular balance.

Vitamin B2 is essential for the body to produce energy, activate other B vitamins, and maintain proper cellular function. To be utilized by the body, common riboflavin must be converted into its active form — riboflavin-5'-phosphate (R5P). Individuals with compromised digestive systems, those taking certain medications, or those with genetic variations that hinder this conversion may not get the most from this vitamin in its conventional form. Thorne Riboflavin 5'-Phosphate provides 36.5 mg of riboflavin already in its active form per capsule, requiring no additional conversion by the body, in a gluten-free, soy-free, and dairy-free vegetable capsule.

✅ Contributes to energy-producing metabolism and the reduction of tiredness and fatigue
✅ Supports the normal functioning of the nervous system and mucous membranes
✅ Participates in protecting cells from oxidative stress
✅ Contributes to the maintenance of normal skin and vision
✅ Coenzymatic (active) form of B2 – high bioavailability
✅ Free from gluten, soy, and dairy – ideal for restrictive diets

The only active ingredient is vitamin B2 in the form of riboflavin-5'-phosphate sodium (R5P), providing 36.5 mg of riboflavin per capsule. R5P is the active coenzyme form of vitamin B2 – the one the body uses directly, without the need for additional conversion by the liver or digestive system. This makes it particularly relevant for people with compromised digestive function, irritable bowel syndrome, Crohn's disease, or those taking medication that interferes with riboflavin absorption. Vitamin B2 is also an essential cofactor for the activation of other B vitamins: it is needed to activate vitamin B6, for the conversion of tryptophan to niacin (B3), and for the conversion of folate into its active forms. The product is not derived from yeast.

The excipients are hydroxypropyl methylcellulose capsule (vegetable cellulose), microcrystalline cellulose, silicon dioxide, and calcium laurate – all of plant or mineral origin. It contains no gluten, soy, dairy, artificial flavors, artificial colors, or unnecessary preservatives.

Informational note: Urine may appear bright yellow during riboflavin supplementation – this is a harmless and normal effect of this vitamin's metabolism, with no health implications.

To note

• Bright yellow urine is a harmless and expected effect of riboflavin – it is no cause for concern.

How to Use: 1 capsule per day or as directed by a healthcare professional.

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What is Thorne's Riboflavin 5'-Phosphate used for?

Thorne's Riboflavin 5'-Phosphate is a vitamin B2 supplement in its active form (R5P), which can contribute to energy production, normal metabolism, the activation of other B vitamins, the maintenance of red blood cells, and cell protection. It is particularly relevant for those who have difficulty converting conventional riboflavin.

Who can benefit from this supplement?

It can be useful for those with persistent fatigue, compromised digestive function, genetic variants affecting B vitamin metabolism (such as MTHFR variants), or those taking medication that may interfere with riboflavin absorption. People with frequent migraines, anemia, skin or mucous membrane disorders, burnout syndrome, or high homocysteine levels may benefit from an adequate intake of active B2 — always in addition to medical follow-up.

What is the difference between conventional riboflavin and riboflavin-5'-phosphate (R5P)?

Conventional riboflavin requires conversion by the digestive system to become active. R5P is already in the coenzyme form and is directly utilized by the body. For individuals with compromised digestive function or genetic variants that hinder this conversion, R5P may be the preferred option.

* NRV (Nutrient Reference Value)

** VRN not established.

Food supplements are not a substitute for a varied and balanced diet or a healthy lifestyle. If you are pregnant or breastfeeding, please contact your doctor before taking the supplements. Not recommended in cases of hypersensitivity or allergy to any of the ingredients in the formulation or when interactions of another product with any of the constituents of the formulation are described. Keep out of the reach and sight of children. Store in a cool, dry place, protected from light.

The recommended daily dose should not be exceeded.

* NRV (Nutrient Reference Value)

** VRN not established.

Food supplements are not a substitute for a varied and balanced diet or a healthy lifestyle. If you are pregnant or breastfeeding, please contact your doctor before taking the supplements. Not recommended in cases of hypersensitivity or allergy to any of the ingredients in the formulation or when interactions of another product with any of the constituents of the formulation are described. Keep out of the reach and sight of children. Store in a cool, dry place, protected from light.

The recommended daily dose should not be exceeded.