MethylFolate 1,000 mcg 90 Tablets Now
The prices of the products sold include VAT. Depending on your shipping address, the VAT rate may vary at checkout. For more information, click here.
Indicado para:
✅ Adultos que procuram folato na sua forma ativa.
✅ Mulheres em idade fértil, dentro de um plano orientado por um profissional de saúde.
✅ Quem segue uma dieta vegana e procura um suplemento sem ingredientes de origem animal.
Product Information
Methyl Folate 1,000 mcg – Active Folate for Energy, Pregnancy, and Mental Well-being
Methyl Folate 1,000 mcg provides 5-MTHF Quatrefolic®, the biologically active form of folate (vitamin B9), with high absorption and bioavailability. Ideal for supporting cell division, healthy pregnancy, and normal psychological function.
✅ 1000 mcg of 5-MTHF (Quatrefolic®) – highly bioavailable folate
✅ Contributes to the reduction of tiredness and fatigue
✅ Supports psychological function and the immune system
✅ Essential for women of childbearing age and during pregnancy
✅ Vegetable capsules, gluten-free, non-GMO, and suitable for vegans
NOW Foods' Methylfolate 1,000 mcg contains as its sole active ingredient Folate (6S)-5-MTHF Quatrefolic® (1,000 mcg of (6S)-5-MTHF = 1,700 mcg DFE per tablet) — the biologically active form naturally present in food and the human body.
Folate exists in multiple forms: folic acid (the most common synthetic form in conventional supplementation) needs to be converted by the body, through several enzymatic reactions dependent on the MTHFR enzyme, before it can be used. This conversion can be less efficient in people with genetic variants of the MTHFR gene (namely the C677T and A1298C variants), which are relatively common in the general population. (6S)-5-MTHF is the final form of this metabolic pathway — ready to be used directly by the body, without the need for additional conversion.
Quatrefolic® is a patented form of (6S)-5-MTHF produced by Gnosis S.p.A., protected by international patent. It is recognized for its superior stability and its effectiveness demonstrated in bioavailability studies. This form is the same one used by the brain — unlike conventional folic acid, (6S)-5-MTHF can cross the blood-brain barrier, making it relevant for supporting neurological well-being, the production of serotonin, dopamine, and other neurotransmitters, and mood balance.
The excipients — microcrystalline cellulose, vegetable-source stearic acid, and silicon dioxide — are commonly used in pharmaceutical-grade formulations. Ultra-clean formulation: only three ingredients, all of plant or mineral origin.
Important considerations
- Important drug interactions: consult a doctor before using in conjunction with phenobarbital, phenytoin, primidone (antiepileptics), or methotrexate (oncological or immunosuppressant).
- Warning for the elderly and people with impaired vitamin B12 absorption: high doses of folate can mask vitamin B12 deficiency, delaying its diagnosis. Regularly monitor B12 levels during use.
Directions for use: Take 1 capsule daily, or as directed by a healthcare professional.
Nutritional Information
Nutritional Information, *
Folate [1700 mcg DFE (of which 1000 mcg as (6S)5 MTHF, 1667 mcg DFE / 834%
Ingredients:Folate [from 1700 mcg DFE (of which 1000 mcg as (6S)-5-MTHF**) (from Quatrefolic® (6S)-5-MTHF**MTHF = Glucosamine Methyltetrahydrofolate Salt)], Microcrystalline Cellulose, Stearic Acid (vegetable source) and Silicon Dioxide.
How to take
1 comprimido por dia, preferencialmente com uma refeição, ou conforme indicação de um profissional de saúde.
Notices & Recommendations
* NRV — Nutrient Reference Value.
** NRV not established.
💊 Food supplements are not a substitute for a varied and balanced diet or a healthy lifestyle.
🤰 If pregnant or breastfeeding, consult your doctor before taking this supplement.
⚠️ Not recommended in cases of hypersensitivity or allergy to any of the ingredients, or when interactions between another product and any of its constituents have been described.
🕐 Do not exceed the recommended daily dose. Keep out of reach and sight of children.
🌡️ Store in a cool, dry place, away from light.
FAQs
Folate is essential during pregnancy and the pre-conception period for the normal development of the fetal neural tube. Methylfolate in its active form can be a good option, especially for women with the MTHFR variant or who do not tolerate conventional folic acid well. Folate supplementation before and during pregnancy should be guided by an obstetrician or gynaecologist.
Folate can contribute to normal homocysteine metabolism — one of the authorised nutrition claims in the EU. Along with vitamin B12 and vitamin B6, methylfolate is one of the most relevant nutrients for homocysteine metabolism. Those with high levels should supplement under medical supervision and analytical monitoring.
Folic acid is the synthetic form that needs to be converted by the body into 5-MTHF before it can be used. Methylfolate (5-MTHF) is the active form, ready to be used directly — no conversion needed. For people with the MTHFR variant or reduced conversion capacity, methylfolate may be a more effective choice.