Methylguard 180 Caps Thorne Research - Viva Saudável
Methylguard 180 Caps Thorne Research - Viva Saudável
Methylguard 180 Caps Thorne Research - Viva Saudável

Methyl-Guard 180 Capsules Thorne

VeganGluten-freeSoy-free
Thorne

5-MTHF folate and vitamins B12 and B6, which may contribute to normal homocysteine metabolism, with betaine

  • Folate, vitamin B12, vitamin B6 and betaine contribute to normal homocysteine metabolism
  • Folate and vitamin B12 contribute to the reduction of tiredness and fatigue
  • Vitamin B12 contributes to normal functioning of the nervous system and to normal psychological function
75,00€

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Daily dose: 3 capsules a day, under professional supervision60 servings per pack≈ 1,25€ per serving
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Description

5-MTHF Folate with Vitamin B12, B6 and Betaine to support methylation and homocysteine balance — Thorne

Methylation is an essential biochemical process that continuously occurs in the body — involving DNA function, neurotransmitter production, liver detoxification, homocysteine metabolism, and much more. 5-MTHF Folate with Vitamin B12, B6 and Betaine (Methyl-Guard) from Thorne was the first supplement on the market to support methylation with nutrients in their active and bioavailable forms — 5-MTHF folate (Quatrefolic®), methylcobalamin, pyridoxal 5'-phosphate, and betaine (trimethylglycine). This combination can support normal homocysteine metabolism, contributing to cardiovascular, cognitive, and bone well-being. Formulated without gluten, lactose, and soy, with a vegetable capsule, and produced in the USA according to Thorne's quality standards.

Thorne's Methyl-Guard is a vitamin B supplement in its active forms combined with betaine, designed for those who want to support methylation and normal homocysteine metabolism — especially adults with genetic variants affecting folate conversion (such as the MTHFR variant), or anyone who wants to support cardiovascular, cognitive, and bone health with bioavailable nutrients.

Thorne's Methyl-Guard combines four nutrients with distinct and complementary roles in supporting methylation:

5-MTHF Folate (L-5-Methyltetrahydrofolate, Quatrefolic®, 1.2 mg = 2 mg DFE per dose) is the biologically active form of folate, which the body can use directly without the need for metabolic conversion by the MTHFR enzyme. This is particularly relevant for people with genetic variants that reduce the activity of this enzyme (C677T or A1298C variant of the MTHFR gene), making supplementation with conventional folic acid less effective. Folate is an essential cofactor in the homocysteine to methionine remethylation pathways.

Vitamin B12 (as Methylcobalamin, 1.2 mg per dose) is the active form of vitamin B12, which the body can use directly as an enzymatic cofactor. Methylcobalamin acts as a methyl group donor in methylation pathways, being essential for normal homocysteine metabolism, nervous system function, and normal red blood cell formation.

Vitamin B6 (as Pyridoxal 5'-Phosphate, 20.4 mg per dose) is the active coenzymatic form of vitamin B6, an essential cofactor in the transsulfuration pathways of homocysteine — the alternative pathway that converts homocysteine into cysteine and taurine, beneficial amino acids for the body. This active form does not require hepatic conversion, and can be more effective in contexts of methylation support.

Anhydrous Betaine (Trimethylglycine, TMG, 1.8 g per dose) is a natural compound present in foods like beetroot. It functions as a methyl group donor independently of B vitamins, serving as an alternative remethylation pathway for homocysteine to methionine — especially relevant when folate-dependent pathways are compromised.

To consider

  • Interaction with methotrexate: Supplementation with 5-MTHF is not recommended simultaneously with methotrexate in oncology chemotherapy, as it may interfere with its antineoplastic action. Those taking methotrexate for psoriasis or rheumatoid arthritis can safely take folate — always consult your doctor.
  • Intended for adults; consult a healthcare professional in case of pregnancy, breastfeeding, or regular medication before starting.
  • Individuals sensitive to methylation (hypermethylators) may experience symptoms such as anxiety or irritability with high doses — start with lower doses and adjust gradually.

✅ May contribute to normal homocysteine metabolism (folate, B6 and B12)
✅ May support psychological function and nervous system (B12, folate)
✅ May help reduce tiredness and fatigue
✅ Contains 5-MTHF (Metafolin®), methylcobalamin and P5P – bioactive forms
✅ Ideal for those with genetic mutations like MTHFR
✅ Pure formula, without gluten, soy or artificial additives

Thorne Methyl-Guard® is a balanced formula to support cellular methylation, a fundamental biochemical process for gene expression, detoxification, neurotransmitter synthesis, and cardiovascular system regulation.

 

75,00€
Methyl-Guard 180 Capsules Thorne
75,00€

Product information

  • HomocysteineFolate, vitamins B12 and B6 and betaine contribute to normal homocysteine metabolism
  • Tiredness and fatigueFolate and vitamin B12 contribute to the reduction of tiredness and fatigue
  • Methylated forms1200 µg of 5-MTHF, 1200 µg of methylcobalamin, 20.4 mg of pyridoxal 5'-phosphate and 1.8 g of betaine per 3 capsules
  • Gluten, soy and dairy freeHypromellose capsule; 180 capsules, 60 servings of 3 capsules

How to use

Simple and practical.

  1. 1 The Thorne label says 3 capsules twice a day, or as advised by a health professional.
  2. 2 In the EU that dose exceeds the tolerable upper levels for vitamin B6 and folate: we recommend not exceeding 3 capsules a day, with a meal, and using it only under the supervision of a health professional.
Daily dose: 3 capsules a day, under professional supervision60 servings per container≈ 1,25€ per dose

Do not exceed the recommended daily dose. If in doubt, please contact us.

Nutritional information Per 3 capsules %NRV*
Betaine anhydrous (trimethylglycine) 1800 mg **
Folate (L-5-methyltetrahydrofolate) 1200 µg 600% NRV
Vitamin B12 (methylcobalamin) 1200 µg 48000% NRV
Vitamin B6 (pyridoxal 5'-phosphate) 20.4 mg 1457% NRV
% NRV: nutrient reference value
** NRV not established

* NRV — Nutrient Reference Value. ** NRV not established.

Ingredients

Ingredients: Betaine anhydrous (trimethylglycine), calcium citrate, capsule (hypromellose), anti-caking agent (silicon dioxide), anti-caking agent (calcium laurate), pyridoxal 5'-phosphate (vitamin B6), L-5-methyltetrahydrofolate, glucosamine salt (folate), methylcobalamin (vitamin B12). Gluten-free, dairy-free and soy-free.

  • Gluten-freeAccording to the manufacturer
  • Non-GMOAccording to the manufacturer
  • GMPAccording to the manufacturer
  • Original productAuthorized reseller
  • Shipped from the EU No customs within the EU
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Frequently Asked Questions

What our customers ask us about this product
What does Methyl-Guard contain?
Per 3 capsules: 1.8 g of betaine anhydrous (trimethylglycine), 1200 µg of folate as L-5-methyltetrahydrofolate (600% NRV), 1200 µg of vitamin B12 as methylcobalamin (48000% NRV) and 20.4 mg of vitamin B6 as pyridoxal 5'-phosphate (1457% NRV).
How is it taken?
The Thorne label says 3 capsules twice a day, or as advised by a health professional. As that dose exceeds the EU tolerable upper levels for vitamin B6 and folate, we recommend not exceeding 3 capsules a day and using it only under the supervision of a health professional.
How long does one pack last?
180 capsules last 60 days at 3 capsules a day, or 30 days at the label dose (3 capsules twice a day).
Who should not take it or should speak to a doctor first?
Pregnant and breastfeeding women, anyone taking methotrexate as cancer therapy, antiepileptics or levodopa and, in general, anyone taking medication. Given the high vitamin B6 content, it is not intended for prolonged use without medical supervision.
Is it vegan and allergen-free?
According to Thorne, it is gluten-free, dairy-free and soy-free, and the capsule is hypromellose (plant cellulose). Thorne does not state a vegan certification for this product.
What is betaine and why is it in this formula?
Betaine (trimethylglycine) is a compound found in foods such as beetroot and whole grains. Betaine contributes to normal homocysteine metabolism (from 500 mg a day). A daily intake above 4 g can significantly increase blood cholesterol levels.
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Notices and recommendations

  • Adults only, under the supervision of a health professional: 3 capsules contain 20.4 mg of vitamin B6 and 1200 µg of folate, above the tolerable upper levels set by EFSA (12 mg and 1000 µg a day). Do not exceed 3 capsules a day without professional advice.
  • Do not use for prolonged periods without medical supervision (high-dose vitamin B6).
  • A daily intake above 4 g of betaine can significantly increase blood cholesterol levels.
  • If pregnant or breastfeeding, consult your doctor before use.
  • Not recommended together with methotrexate cancer therapy. If you take medication (in particular antiepileptics or levodopa), consult your doctor before use.
  • Do not use in case of hypersensitivity to any of the ingredients.
  • Do not exceed the recommended daily dose. Store in a cool, dry place. Keep out of the reach of children. Food supplements should not be used as a substitute for a varied and balanced diet and a healthy lifestyle.

Food supplement. Food supplements should not be used as a substitute for a varied and balanced diet and a healthy lifestyle. Do not exceed the recommended daily dose. Keep out of the sight and reach of children. If you are pregnant, breastfeeding, ill or taking medication, consult your doctor or pharmacist before use. Not recommended in case of hypersensitivity to any of the ingredients. Store in a cool, dry place, away from light.