Pyridoxal 5 Phosphate 180 Caps Thorne Research
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✅ Individuals with an increased need for active vitamin B6 (e.g., stress, use of certain medications, restrictive diets).
✅ Individuals seeking support for energy metabolism, nervous function, and immunity.
✅ Those experiencing symptoms that may be related to B6 deficiency: fatigue, mood changes, or slow metabolism.
Product Information
Pyridoxal-5-Phosphate – Thorne | Active Vitamin B6 for Metabolism, Immunity & Energy
This is a vitamin B6 supplement in its biologically active form (P5P), which does not require liver conversion to be utilized by the body. It can be beneficial for those who want to support energy production, normal nervous system function, hormonal balance, or protein metabolism in their daily lives.
Vitamin B6 is essential for the body to function properly – from energy production to neurotransmitter synthesis, hormonal regulation, and protein metabolism. To be used by the body, common vitamin B6 (pyridoxine) must be converted into its active form, pyridoxal-5'-phosphate (P5P). Individuals with compromised liver function, genetic variations that hinder this conversion, or increased vitamin B6 needs may not be able to perform this transformation effectively. Thorne's Pyridoxal 5'-Phosphate provides 33.8 mg of P5P per capsule – the active form, ready to be utilized by the body – in a gluten-free, soy-free, and dairy-free vegetable capsule. One to three capsules daily can easily integrate into any routine.
✅ May contribute to energy-yielding metabolism and reduction of tiredness and fatigue.
✅ Supports normal nervous system function and psychological function
✅ Participates in the regulation of hormonal activity
✅ May support normal red blood cell formation and protein metabolism
✅ Coenzyme (active) form of B6 – better absorption and efficacy
✅ Free from gluten, lactose, soy, and preservatives
Pyridoxal 5'-Phosphate (P5P) is the active form of vitamin B6, ready for use by the body, without the need for liver conversion.
The only active ingredient in this supplement is vitamin B6 in the form of pyridoxal-5'-phosphate (P5P), providing 33.8 mg per capsule. P5P is the active coenzyme form of vitamin B6 – the one the body uses directly, without the need for additional liver conversion. This makes it particularly relevant for people with reduced liver function, genetic variants that affect B vitamin metabolism (such as MTHFR gene variants), or anyone who simply wants to ensure a direct supply of the most usable form of this vitamin. Vitamin B6 is essential for over 100 enzymatic reactions in the body, including the synthesis of neurotransmitters like serotonin and dopamine, hemoglobin production, the formation of the myelin sheath surrounding nerve cells, and homocysteine metabolism. The product is not derived from yeast.
Excipients are microcrystalline cellulose, hydroxypropyl methylcellulose capsule (vegetable cellulose), calcium laurate, and silicon dioxide – all of vegetable or mineral origin. It does not contain gluten, soy, dairy, eggs, tree nuts, or shellfish.
To consider
- Vitamin B6 doses above 200 mg/day can inhibit breast milk production – do not exceed the recommended dosage during breastfeeding without medical advice.
- If pregnant, consult a healthcare professional before starting supplementation.
- No adverse interactions are known with the P5P form at usual doses – unlike what was observed with very high doses of pyridoxine (common form), for which reversible neuropathies were described.
- This product is not derived from yeast – relevant for those with yeast sensitivity.
Nutritional Information
Vitamin B 6 (with Pyridoxal 5'Phosphate), 33.8 mg / **
Ingredients:Pyridoxal-5-phosphate, microcrystalline cellulose (filler), hypromellose capsule (vegetable), calcium laurate (superplasticizer), silicon dioxide (release agent
How to take
1 Capsule
Notices & Recommendations
* NRV — Nutrient Reference Value.
** NRV not established.
💊 Food supplements are not a substitute for a varied and balanced diet or a healthy lifestyle.
🤰 If pregnant or breastfeeding, consult your doctor before taking this supplement.
⚠️ Not recommended in cases of hypersensitivity or allergy to any of the ingredients, or when interactions between another product and any of its constituents have been described.
🕐 Do not exceed the recommended daily dose. Keep out of reach and sight of children.
🌡️ Store in a cool, dry place, away from light.
FAQs
Pyridoxal 5'-Phosphate is a vitamin B6 supplement in its active form (P5P), which can contribute to energy production, normal nervous system function, hormonal balance, protein metabolism, and red blood cell formation. It is particularly relevant for those who have difficulty converting common pyridoxine into its active form.
It may be useful for individuals with compromised liver function, genetic variants such as MTHFR affecting B-vitamin metabolism, women with premenstrual syndrome (PMS) symptoms, people with persistent fatigue, mood imbalances, or elevated homocysteine levels. Conditions such as peripheral neuropathy, premenstrual syndrome, anaemia, anxiety, and neurotransmitter imbalances can benefit from adequate B6 intake — always in addition to medical supervision.
Yes. Vitamin B6 and magnesium are frequently used together, especially in the context of supporting women's well-being and mood regulation. The combination of these two nutrients can complement their effects as part of a wellness routine — consult a healthcare professional for personalized guidance.