Methylguard 180 Caps Thorne Research
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Product Information
5-MTHF Folate with Vitamin B12, B6 and Betaine to support methylation and homocysteine balance — Thorne
Methylation is an essential biochemical process that continuously occurs in the body — involving DNA function, neurotransmitter production, liver detoxification, homocysteine metabolism, and much more. 5-MTHF Folate with Vitamin B12, B6 and Betaine (Methyl-Guard) from Thorne was the first supplement on the market to support methylation with nutrients in their active and bioavailable forms — 5-MTHF folate (Quatrefolic®), methylcobalamin, pyridoxal 5'-phosphate, and betaine (trimethylglycine). This combination can support normal homocysteine metabolism, contributing to cardiovascular, cognitive, and bone well-being. Formulated without gluten, lactose, and soy, with a vegetable capsule, and produced in the USA according to Thorne's quality standards.
Thorne's Methyl-Guard is a vitamin B supplement in its active forms combined with betaine, designed for those who want to support methylation and normal homocysteine metabolism — especially adults with genetic variants affecting folate conversion (such as the MTHFR variant), or anyone who wants to support cardiovascular, cognitive, and bone health with bioavailable nutrients.
Thorne's Methyl-Guard combines four nutrients with distinct and complementary roles in supporting methylation:
5-MTHF Folate (L-5-Methyltetrahydrofolate, Quatrefolic®, 1.2 mg = 2 mg DFE per dose) is the biologically active form of folate, which the body can use directly without the need for metabolic conversion by the MTHFR enzyme. This is particularly relevant for people with genetic variants that reduce the activity of this enzyme (C677T or A1298C variant of the MTHFR gene), making supplementation with conventional folic acid less effective. Folate is an essential cofactor in the homocysteine to methionine remethylation pathways.
Vitamin B12 (as Methylcobalamin, 1.2 mg per dose) is the active form of vitamin B12, which the body can use directly as an enzymatic cofactor. Methylcobalamin acts as a methyl group donor in methylation pathways, being essential for normal homocysteine metabolism, nervous system function, and normal red blood cell formation.
Vitamin B6 (as Pyridoxal 5'-Phosphate, 20.4 mg per dose) is the active coenzymatic form of vitamin B6, an essential cofactor in the transsulfuration pathways of homocysteine — the alternative pathway that converts homocysteine into cysteine and taurine, beneficial amino acids for the body. This active form does not require hepatic conversion, and can be more effective in contexts of methylation support.
Anhydrous Betaine (Trimethylglycine, TMG, 1.8 g per dose) is a natural compound present in foods like beetroot. It functions as a methyl group donor independently of B vitamins, serving as an alternative remethylation pathway for homocysteine to methionine — especially relevant when folate-dependent pathways are compromised.
To consider
- Interaction with methotrexate: Supplementation with 5-MTHF is not recommended simultaneously with methotrexate in oncology chemotherapy, as it may interfere with its antineoplastic action. Those taking methotrexate for psoriasis or rheumatoid arthritis can safely take folate — always consult your doctor.
- Intended for adults; consult a healthcare professional in case of pregnancy, breastfeeding, or regular medication before starting.
- Individuals sensitive to methylation (hypermethylators) may experience symptoms such as anxiety or irritability with high doses — start with lower doses and adjust gradually.
✅ May contribute to normal homocysteine metabolism (folate, B6 and B12)
✅ May support psychological function and nervous system (B12, folate)
✅ May help reduce tiredness and fatigue
✅ Contains 5-MTHF (Metafolin®), methylcobalamin and P5P – bioactive forms
✅ Ideal for those with genetic mutations like MTHFR
✅ Pure formula, without gluten, soy or artificial additives
Thorne Methyl-Guard® is a balanced formula to support cellular methylation, a fundamental biochemical process for gene expression, detoxification, neurotransmitter synthesis, and cardiovascular system regulation.
Nutritional Information
Vitamin B12 (as methylcobalamin), 1200 µg / 48000%
Betaine, 1800 mg / **
Vitamin B6 (Pyridoxal 5- Phosphate), 20.4 mg / 1457%
Ingredients:Trimethylglycine, hypromellose capsule (vegetable), calcium citrate laurate (flow agent), silicon dioxide (anti-caking agent), pyridoxal-5-phosphate, 5-MTHF-glucosamine, methylcobalamin
How to take
3 capsules per day
Notices & Recommendations
* NRV — Nutrient Reference Value.
** NRV not established.
💊 Food supplements are not a substitute for a varied and balanced diet or a healthy lifestyle.
🤰 If pregnant or breastfeeding, consult your doctor before taking this supplement.
⚠️ Not recommended in cases of hypersensitivity or allergy to any of the ingredients, or when interactions between another product and any of its constituents have been described.
🕐 Do not exceed the recommended daily dose. Keep out of reach and sight of children.
🌡️ Store in a cool, dry place, away from light.
FAQs
Elevated homocysteine is a marker for cardiovascular and cognitive risk. 5-MTHF folate, vitamin B12 (methylcobalamin), vitamin B6 (P5P), and betaine are the four most studied nutrients in supporting normal homocysteine metabolism. Individuals with elevated levels should supplement under medical supervision and with regular analytical monitoring.
Folate can contribute to normal psychological function and the reduction of fatigue. Vitamin B12 can contribute to the normal functioning of the nervous system. Those experiencing mental fatigue or difficulty concentrating may consider this supplement as part of a cognitive wellness approach, especially if they have a B12 deficiency or an MTHFR variant.
Folate is an essential nutrient during pregnancy. However, the doses present in this formula are high and intended for adults in general - it is mandatory to consult a gynaecologist or doctor before using during pregnancy or during family planning.